Bierhoff E, Walljasper U, Hofmann D, Vogel J, Wernert N, Pfeifer U
Department of Pathology, Rheinische Friedrich-Willhelms-Universität, Bonn, Germany.
Prostate. 1997 Jun 1;31(4):234-40. doi: 10.1002/(sici)1097-0045(19970601)31:4<234::aid-pros4>3.0.co;2-k.
A "reawakening" of ontogenetic processes in the development of BPH is still in debate. Therefore, morphological analogies of fetal prostate stroma and nodular stromal proliferates in BPH were investigated.
Fetal prostates (n = 30; weeks 12-40 of gestation) and stromal nodules of benign prostatic hyperplasia (n = 375 from autopsies, n = 100 from biopsies) were investigated by histo- and immunohistochemistry with special regard to cytoskeletal (alpha-actin, desmin, myosin, and vimentin), neuronal (S-100 protein), neuroendocrine (neuron-specific enolase), leukocytic (CD3, CD20, and CD68) and vascular (CD34, BMA-120, and factor VIII) antigens.
The developing fetal prostate stroma consists of immature mesenchymal cells up to week 17 of gestation, followed by fibroblastic and fibromuscular stromal cells up to week 25 of gestation and predominantly smooth-muscular cells until the end of gestation. Stromal nodules occur as immature mesenchymal, fibroblastic, fibromuscular, and smooth-muscular, suggestive of a maturational process. The fetal prostate stroma and the stromal nodules present, with an increasing degree of maturation, a similar vascular pattern and a similar occurrence of CD3 (T-lymphocytes), CD20 (B-lymphocytes), CD68 (macrophages), S-100, and neuron-specific enolase-positive cells.
The data suggest that ontogenetic processes are recapitulated in the development of stromal nodules in benign prostatic hyperplasia, supporting the idea of a "re-awakening" of fetal processes in BPH.
良性前列腺增生（BPH）发育过程中个体发生过程的“重新激活”仍存在争议。因此，对胎儿前列腺基质与BPH中结节性基质增生的形态学相似性进行了研究。
通过组织学和免疫组织化学研究胎儿前列腺（n = 30；妊娠12 - 40周）以及良性前列腺增生的基质结节（尸检标本n = 375，活检标本n = 100），特别关注细胞骨架（α - 肌动蛋白、结蛋白、肌球蛋白和波形蛋白）、神经元（S - 100蛋白）、神经内分泌（神经元特异性烯醇化酶）、白细胞（CD3、CD20和CD68）以及血管（CD34、BMA - 120和因子VIII）抗原。
发育中的胎儿前列腺基质在妊娠17周前由未成熟的间充质细胞组成，随后在妊娠25周前由成纤维细胞和纤维肌性基质细胞组成，直至妊娠末期主要为平滑肌细胞。基质结节表现为未成熟的间充质、成纤维、纤维肌性和平滑肌性，提示存在成熟过程。胎儿前列腺基质和基质结节随着成熟程度的增加，呈现出相似的血管模式以及相似的CD3（T淋巴细胞）、CD20（B淋巴细胞）、CD68（巨噬细胞）、S - 100和神经元特异性烯醇化酶阳性细胞的出现情况。
数据表明，良性前列腺增生中基质结节的发育重现了个体发生过程，支持了BPH中胎儿过程“重新激活”的观点。
