Benz M, Giefer T, Bierhoff E, Vogel J, Gehring C, Nuri M, Kraus A, Pfeifer U
Pathologisches Institut, Universität Bonn.
Verh Dtsch Ges Pathol. 1993;77:111-6.
The expression of immunohistochemical markers for cytoskeletal differentiation and that of neuroendocrine- and immunological cells showed in general the same tendency in the 4 types of prostatic stromal nodules: missing or low expression in immature-mesenchymal-, distinct augmentation in fibroblastic-, a maximum in fibro-muscular- and a slight decline in smooth-muscular nodules. These results are in agreement with developmental sequences, revealed by immunohistochemical investigations of fetal prostates, and seem to confirm the hypothesis that the four types of stromal nodules represent successive degrees of maturation, recapitulating ontogenetic processes.
细胞骨架分化免疫组化标志物以及神经内分泌和免疫细胞的表达，在4种前列腺基质结节中总体呈现相同趋势：在未成熟间充质结节中缺失或低表达，在成纤维细胞结节中明显增加，在纤维肌结节中达到最高，在平滑肌结节中略有下降。这些结果与胎儿前列腺免疫组化研究揭示的发育序列一致，似乎证实了这一假说，即这四种基质结节代表了连续的成熟程度，概括了个体发育过程。
