Mjahed K, el Harrar N, Idali B, Laouissi F, Benaguida M, Amraoui A
Département d'anesthésie-réanimation, CHU Ibn Rochd Casablanca, Maroc.
Ann Fr Anesth Reanim. 1996;15(7):1018-21. doi: 10.1016/s0750-7658(96)89471-8.
To compare the efficacy of oral ondansetron with oral metoclopramide for the prevention of postoperative vomiting and nausea in children undergoing strabismus surgery.
Prospective, randomized, double-blind trial.
Thirty children of physical class 1, age 9 +/- 4 years, scheduled for strabismus surgery, were randomized into two groups (ondansetron and metoclopramide).
In the ondansetron group, the children received the first oral dose of ondansetron (4 mg) 1 hour before induction of anaesthesia and the other doses 8 and 16 hours later. In the metoclopramide group, children received metoclopramide (5 mg) in the same conditions. Anaesthesia was induced with thiopentone, vecuronium and fentanyl and maintained with halothane and N2O/O2. Patients were evaluated by an independent observer for nausea and emesis in recovery room (0-2 h) and on the ward. The adverse effects of oral ondansetron and metoclopramide were assessed.
There were non-significant differences between the two groups for incidence of nausea and vomiting (40% and 53% in ondansetron group versus 33 and 60% in metoclopramide group, respectively.
Unlike intravenous ondansetron, oral ondansetron is not superior to metoclopramide for the prevention of nausea and vomiting caused by strabismus surgery in children.
比较口服昂丹司琼与口服甲氧氯普胺预防斜视手术患儿术后恶心和呕吐的疗效。
前瞻性、随机、双盲试验。
30名身体状况为1级、年龄9±4岁、计划进行斜视手术的儿童被随机分为两组（昂丹司琼组和甲氧氯普胺组）。
在昂丹司琼组，患儿在麻醉诱导前1小时口服首剂昂丹司琼（4毫克），另外两剂分别在8小时和16小时后服用。在甲氧氯普胺组，患儿在相同条件下服用甲氧氯普胺（5毫克）。采用硫喷妥钠、维库溴铵和芬太尼诱导麻醉，并用氟烷和N2O/O2维持麻醉。由一名独立观察者在恢复室（0至2小时）和病房对患者的恶心和呕吐情况进行评估。评估口服昂丹司琼和甲氧氯普胺的不良反应。
两组在恶心和呕吐发生率方面无显著差异（昂丹司琼组分别为40%和53%，甲氧氯普胺组分别为33%和60%）。
与静脉注射昂丹司琼不同，口服昂丹司琼在预防儿童斜视手术引起的恶心和呕吐方面并不优于甲氧氯普胺。
