Surbled M, Lejus C, Milpied B, Pannier M, Souron R
Service d'anesthésie-réanimation chirurgicale, Hôtel Dieu, Nantes, France.
Ann Fr Anesth Reanim. 1996;15(7):1095-8. doi: 10.1016/s0750-7658(96)89482-2.
The authors report a toxic epidermal necrolysis (TEN) due to ampicillin (Agram) in a 2-year-old child. During the acute phase a septic syndrome occurred. The severity of the clinical and biological symptoms led to the administration of antibiotics, their systematic use remaining controversial. Recovery was favourable in a paediatric burn centre. Sequelae were minor. TEN, the physiopathological mechanism of which remaining still unknown, may carry a vital risk.
作者报告了一名2岁儿童因氨苄西林（阿格拉姆）导致中毒性表皮坏死松解症（TEN）的病例。急性期出现了败血症综合征。临床和生物学症状的严重程度导致使用了抗生素，但其系统性使用仍存在争议。在一家儿科烧伤中心病情顺利康复。后遗症轻微。TEN的生理病理机制尚不清楚，可能会带来生命危险。
