1,8-萘啶。III. 具有抗炎活性的N,N-二烷基-5-氯[1,2,4]三唑并[4,3-a][1,8]萘啶-6-甲酰胺
1,8-Naphthyridines. III. N,N-dialkyl-5-chloro[1,2,4]-triazolo[4,3-a][1,8]naphthyridine-6-carboxa mides with anti-inflammatory activity.
作者信息
Di Braccio M, Roma G, Grossi G, Ghia M, Mattioli F
机构信息
Istituto di Scienze Farmaceutiche dell'Università, Genova, Italy.
出版信息
Farmaco. 1997 Jan;52(1):49-53.
PMID:9181682
Abstract
Fifteen N,N-dialkyl-5-chloro[1,2,4]triazolo[4,3-a][1,8]naphthyridine-6-carboxami des (7a-o) were synthesized through the cyclocondensation of the corresponding N,N-dialkyl-2,4-dichloro-1,8-naphthyridine-3-carboxamides with proper hydrazides, in order to evaluate their anti-inflammatory, antiaggressive, and analgesic properties. Four of the compounds tested showed a statistically significant and dose-dependent anti-inflammatory activity.
摘要
通过相应的N,N-二烷基-2,4-二氯-1,8-萘啶-3-甲酰胺与适当的酰肼进行环缩合反应，合成了15种N,N-二烷基-5-氯[1,2,4]三唑并[4,3-a][1,8]萘啶-6-甲酰胺（7a-o），以评估它们的抗炎、抗侵袭和镇痛特性。所测试的化合物中有四种显示出具有统计学意义的剂量依赖性抗炎活性。
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