Inozemtsev A N, Voronina T A, Pragina L L, Krutikova I A, Tushmalova N A
Eksp Klin Farmakol. 1996 Nov-Dec;59(6):3-5.
Emotional stress was caused in rats by changing the location of the gate in the shuttle chamber through which training had been accomplished in the previous experiments. The procedure led to disorder of the avoidance response (AR) and increase of intertrial responses (ITR). Phenazepam (0.1 mg/kg) prevented increase in the number of ITS. Piracetam (300 mg/kg) reduced the sharp growth of ISR but, in contrast to phenazepam, it provided a higher level of AR reproduction. The ISR were greater in piracetam than in phenazepam administration. The obtained results show that the suggested model allows the difference in the effects of piracetam and phenazepam to be disclosed.
通过改变穿梭箱中门的位置给大鼠造成情绪应激，此前实验曾通过该门进行训练。此程序导致回避反应（AR）紊乱以及试验间期反应（ITR）增加。非那西泮（0.1毫克/千克）可防止ITR数量增加。吡拉西坦（300毫克/千克）可降低ISR的急剧增长，但与非那西泮不同的是，它能使AR重现水平更高。吡拉西坦组的ISR高于非那西泮给药组。所得结果表明，所提出的模型能够揭示吡拉西坦和非那西泮作用的差异。
