Voronina T A, Molodavkin G M, Borlikova G G, Ostrovskaia R U, Tushmalova N A, Naznamov G G
Laboratory of Psychopharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Eksp Klin Farmakol. 2000 Mar-Apr;63(2):9-11.
The effect of piracetam at various doses on the behavioral and electrophysiological characteristics was studied, including the development of passive and active avoidance conditional reflexes in rats, their behavior in conflict situations, and the transcallosal evoked response (TER) in rabbit brain. In the dose range from 50 to 300 mg/kg, piracetam improved the avoidance performance of both types and produced a dose-dependent increase in the TER amplitude, but did not affect the behavior of rats in conflict situations. As the drug dose was increased to 400-1000 mg/kg, the positive learning influence disappeared (sometimes the effect was even negative) and the TER increase changed to decrease. In contrast, the conflict situation tests revealed pronounced anxiolytic activity of piracetam at elevated doses. Thus, the nootropic and anxiolytic effects of piracetam (and, probably, of the other tranquilizers as well) do not coexist and are significantly shifted relative to one another on the dose scale, being probably realized via different mechanisms.
研究了不同剂量的吡拉西坦对行为和电生理特征的影响，包括大鼠被动和主动回避条件反射的形成、它们在冲突情境中的行为以及兔脑胼胝体诱发反应（TER）。在50至300mg/kg的剂量范围内，吡拉西坦改善了两种类型的回避表现，并使TER振幅呈剂量依赖性增加，但不影响大鼠在冲突情境中的行为。当药物剂量增加到400 - 1000mg/kg时，积极的学习影响消失（有时甚至产生负面效果），TER增加变为减少。相反，冲突情境测试显示吡拉西坦在高剂量时有明显的抗焦虑活性。因此，吡拉西坦（可能还有其他镇静剂）的益智和抗焦虑作用并不共存，并且在剂量范围内彼此显著偏移，可能通过不同机制实现。
