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[The effect of perftoran on the resistance of mice to GABA receptor antagonists and on the antidote activity of anticonvulsant agents].

作者信息

Golovko A I, Kliuntina T V, Ivanov M B, Sofronov G A, Sviderskiĭ O A, Shilov V V

出版信息

Eksp Klin Farmakol. 1996 Nov-Dec;59(6):34-7.

PMID:9181871
Abstract

Perfluorane (a phenobarbital-type inducer of the microsomal enzyme system) raised the resistance of mice to the toxic effect of picrotoxin and bicucullin in 7 days after injection. The antidote effect of diazepam and phenobarbital increased under such conditions. In experiments in vitro a modulatory effect of perftorane on the central muscarine and benzodiazepine receptors was demonstrated.

摘要

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