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[The appearance of a fracture of radioresistant cells in a fibroblast population irradiated at high doses].

作者信息

Tyrsina E G, Kalendo G S, Slanina S V

出版信息

Radiats Biol Radioecol. 1997 Mar-Apr;37(2):207-12.

PMID:9181963
Abstract

Two sublines of Djungarian DEF 4/21 hamster cells survived after gamma irradiation with the doses of 10 and 20 Gy were obtained. The survived cell posterity (SCP) of both cell lines are considerably more clonogenic. They show a higher proliferative activity and a shorter period of generation than the control cells. The sublines are several times more radioresistant as compared to the original cells. After exposure to high doses of radiation, the cell culture of the SCP exhibits a 17 to 20% high-resistant fraction. Supposedly, the cells of this fraction are responsible for repopulation after exposure to lethal doses of gamma irradiation.

摘要

相似文献

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The role of chromatin structural changes in acquired radioresistance of cells.染色质结构变化在细胞获得性放射抗性中的作用。
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