Hundeiker M, Lippold A, Peters A
Fachklinik Hornheide, Westfälische Wilhelms-Universität, Münster.
Hautarzt. 1997 Mar;48(3):171-4. doi: 10.1007/s001050050565.
We treated 8123 patients with invasive malignant melanoma were treated up to 1995. 2200 had invasive melanomas with less than 0.75 mm Breslow thickness; of these, 45 developed metastases. Three had second primary tumors with greater thickness. One case showed metastasis from another tumor. In two cases the metastases were not ascertained histologically. The remaining 39 cases showed some peculiarities: a greater proportion of late and of internal (as contrasted to regional) metastases. Most of these primary tumors had a Breslow thickness of more than 0.5 mm and were Clark level III or even IV. Male patients and primary tumor sites in the area of head and neck were significantly over-represented.
截至1995年,我们共治疗了8123例侵袭性恶性黑色素瘤患者。其中2200例患者的侵袭性黑色素瘤Breslow厚度小于0.75mm;在这些患者中,有45例发生了转移。3例患者有厚度更大的第二原发性肿瘤。1例患者显示为来自另一肿瘤的转移。2例患者的转移灶未通过组织学确诊。其余39例患者表现出一些特点:晚期转移和远处(相对于区域)转移的比例更高。这些原发性肿瘤大多Breslow厚度超过0.5mm,且为Clark III级甚至IV级。男性患者以及头颈部区域的原发性肿瘤部位明显比例过高。