Lewin G, Schaeffer C, Dacquet C
Laboratoires de Phamacognosie, Faculté de Pharmacie, Caen, France.
J Nat Prod. 1997 Apr;60(4):419-20. doi: 10.1021/np960482l.
The natural indole alkaloid (-)-tabersonine (1) easily provided (-)-decahydrotabersonine (4a), isolated as dihydrochloride (4b), by catalytic hydrogenation. Saponification of 4a led to the beta-amino acid 5. A binding study of 1, 4b, and 5 on various receptors and ionic channels showed that none of the compounds had a strong affinity for the receptors tested.
天然吲哚生物碱（-）-长春花碱（1）通过催化氢化反应可轻松制得（-）-十氢长春花碱（4a），其以二盐酸盐（4b）形式分离得到。4a经皂化反应生成β-氨基酸5。对1、4b和5在各种受体及离子通道上的结合研究表明，这些化合物对所测试的受体均无强烈亲和力。
