Halfon P, Pol S, Sayada C, Izopet J, Rostaing L, Ouzan D
Laboratoire Alphabio, Marseille.
Nephrologie. 1997;18(2):53-8.
Viral infections due to hepatitis C virus in hemodialysis patients are frequent and have a potential risk of progression towards chronicity. Biochemical and viral markers of infection, are transaminases level, anti-HCV serology and the detection of HCV RNA, respectively. A rational strategy based on routine use of these three diagnostic tools is proposed in order to avoid unnecessary assays and to increase in the case of health cost control, the cost/efficacy ratio. The latter is set up, in the sero-negative hemodialysed, on the early detection of infection by the hepatitis C virus in order to consider of a therapeutic which is able to cure patients and to avoid the ineluctable passage towards chronicity; in hemodialysed with positive HCV serology, the detection of HCV RNA allows to establish the infectiosity status of these hemodialysis patients. It is therefore very important to evaluate prospectively this diagnosis approach in hemodialysis patients.
血液透析患者中丙型肝炎病毒引起的病毒感染很常见，并且有向慢性化发展的潜在风险。感染的生化和病毒标志物分别是转氨酶水平、抗-HCV血清学和HCV RNA检测。为避免不必要的检测并在控制医疗成本的情况下提高成本效益比，提出了一种基于常规使用这三种诊断工具的合理策略。后者是在血清阴性的血液透析患者中，通过早期检测丙型肝炎病毒感染来建立的，以便考虑采用能够治愈患者并避免不可避免地发展为慢性的治疗方法；在HCV血清学阳性的血液透析患者中，检测HCV RNA可以确定这些血液透析患者的感染状态。因此，前瞻性地评估这种血液透析患者的诊断方法非常重要。
