Seifert G
Institute of Pathology, University of Hamburg, Germany.
Pathol Res Pract. 1996 Dec;192(12):1211-7. doi: 10.1016/S0344-0338(96)80153-1.
Concerning the hypothesis that distinct types of salivary gland cysts may be the starting point of a salivary gland tumour, a histological examination of 1,661 salivary gland cysts was performed in order to analyse the cell types and their proliferative activity. Epithelial alterations were found especially in salivary duct cysts of parotid gland and in mucous retention cysts of minor salivary glands. Characteristic cellular changes were epithelial metaplasias (goblet cells, clear cells, squamous cells) and focal epithelial proliferations with plump or papillary plaques projecting into the cyst lumen. Only in one case had a mucoepidermoid carcinoma developed in the wall of a parotid duct cyst. The epithelial metaplasia and focal proliferative activity in salivary duct cysts is comparable to similar alterations in odontogenic cysts as possible early manifestation of a tumour, especially of an ameloblastoma or mucoepidermoid carcinoma. The differential diagnosis of salivary duct cysts must take primarily cystadenomas and cystic mucoepidermoid carcinomas of well-differentiated type into account.
关于不同类型唾液腺囊肿可能是唾液腺肿瘤起始点的假说，对1661个唾液腺囊肿进行了组织学检查，以分析细胞类型及其增殖活性。上皮改变尤其见于腮腺的唾液腺导管囊肿和小唾液腺的黏液潴留囊肿。特征性细胞变化为上皮化生（杯状细胞、透明细胞、鳞状细胞）以及局灶性上皮增生，有丰满或乳头状斑块突入囊腔。仅1例在腮腺导管囊肿壁发生了黏液表皮样癌。唾液腺导管囊肿中的上皮化生和局灶性增殖活性与牙源性囊肿中的类似改变相当，可能是肿瘤尤其是成釉细胞瘤或黏液表皮样癌的早期表现。唾液腺导管囊肿的鉴别诊断必须首先考虑囊腺瘤和高分化型囊性黏液表皮样癌。
