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Case study: the use of melatonin in a boy with refractory bipolar disorder.

作者信息

Robertson J M, Tanguay P E

机构信息

Department of Psychiatry, University of Louisville School of Medicine, KY, USA.

出版信息

J Am Acad Child Adolesc Psychiatry. 1997 Jun;36(6):822-5. doi: 10.1097/00004583-199706000-00020.

DOI:10.1097/00004583-199706000-00020
PMID:9183138
Abstract

The authors describe the clinical course of a 10-year-old boy with bipolar disorder diagnosed at age 5 years. Lithium, carbamazepine, and valproic acid were ineffective or caused intolerable side effects. A trial of melatonin led to rapid relief of insomnia and aborted a manic episode. He has continued to take melatonin and adjunctive alprazolam for 15 months without recurrence of insomnia or mania. Affective disorders involving circadian dysregulation may respond to interventions that restore a normal sleep-wake cycle. Literature supporting this hypothesis is cited.

摘要

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