Sinha G, Corry P, Subesinghe D, Wild J, Levene M I
Department of Paediatrics, Leeds General Infirmary, USA.
Dev Med Child Neurol. 1997 Apr;39(4):259-62. doi: 10.1111/j.1469-8749.1997.tb07422.x.
Little is known about the prevalence of cerebral palsy (CP) within ethnic subgroups born in Britain. The Yorkshire Regional Cerebral Palsy Register has ascertained all cases of CP in children born within the Regional Health Authority boundary in 1985 to 1987 inclusive and diagnosed by 5 years of age. Birth registrations recorded by ethnic subgroups allowed us to determine the prevalence of CP within the Bradford District Health Authority (BDHA) boundaries by Asian and non-Asian ethnic subgroups. All the children with CP in BDHA were examined by one individual and careful family pedigrees recorded. We noted that BDHA had a high prevalence of CP; 3.87 to 4.16 per 1000. The prevalences in the non-Asian and Asian populations were 3.18, and between 5.48 and 6.42, per 1000, respectively. This difference was statistically significant (P = 0.03). First cousin marriages occurred in 15 of the 39 Asian families (51.7%) and nine of these families had another first or second degree family member with a similar type of CP to the index child. There was no consanguinity in the non-Asian families. These data highlight the increased need for services in some ethnic populations living in Britain and the likely genetic aetiology of a significant proportion of cases of CP in Asian families.
对于在英国出生的不同种族亚组中脑瘫（CP）的患病率，人们了解甚少。约克郡地区脑瘫登记处已确定了1985年至1987年（含）在地区卫生局管辖范围内出生且在5岁前被诊断出的所有脑瘫患儿病例。按种族亚组记录的出生登记信息使我们能够确定在布拉德福德地区卫生局（BDHA）辖区内亚洲和非亚洲种族亚组中脑瘫的患病率。BDHA内所有脑瘫患儿均由一人进行检查，并记录详细的家族谱系。我们注意到BDHA的脑瘫患病率很高；每1000人中有3.87至4.16例。非亚洲人群和亚洲人群的患病率分别为每1000人中有3.18例以及5.48至6.42例。这种差异具有统计学意义（P = 0.03）。在39个亚洲家庭中，有15个家庭存在近亲结婚（51.7%），其中9个家庭还有另一位一级或二级家庭成员患有与索引患儿类似类型的脑瘫。非亚洲家庭中不存在近亲结婚情况。这些数据凸显了英国一些种族人群对服务需求的增加，以及亚洲家庭中相当一部分脑瘫病例可能的遗传病因。
