Fujikawa T, Yanai I, Yamawaki S
Department of Psychiatry and Neurosciences, Hiroshima University School of Medicine, Japan.
Stroke. 1997 Jun;28(6):1123-5. doi: 10.1161/01.str.28.6.1123.
We previously found that silent cerebral infarction (SCI) was present in most of the patients older than 50 years with major depression who were examined. The present study was designed to clarify the relationship between psychosocial stressors and SCI in patients with major depression.
Forty-two patients with unipolar depression underwent MRI and were classified as SCI-negative (n = 19) or SCI-positive (n = 23). The SCI-positive group was subclassified into those with moderate SCI (n = 16) and those with severe SCI (n = 7). The relationship between the patients' DSM-III-R axis IV scores and SCI was evaluated.
The axis IV score was significantly lower in the SCI-positive group than in the SCI-negative group (P < .05). Within the SCI-positive group, the mean axis IV score was significantly lower in those with severe SCI than in those with moderate SCI (P < .05).
Our findings suggest that depression in patients with SCI involves more neurological factors than psychosocial stressors.
我们之前发现，在大多数接受检查的50岁以上重度抑郁症患者中存在无症状性脑梗死（SCI）。本研究旨在阐明重度抑郁症患者心理社会应激源与SCI之间的关系。
42例单相抑郁症患者接受了MRI检查，并被分为SCI阴性组（n = 19）或SCI阳性组（n = 23）。SCI阳性组又被细分为中度SCI患者（n = 16）和重度SCI患者（n = 7）。评估患者的DSM-III-R轴IV评分与SCI之间的关系。
SCI阳性组的轴IV评分显著低于SCI阴性组（P < .05）。在SCI阳性组中，重度SCI患者的平均轴IV评分显著低于中度SCI患者（P < .05）。
我们的研究结果表明，SCI患者的抑郁症涉及更多的神经学因素而非心理社会应激源。
