Chander A, Dhariwal K R, Viswanathan R, Venkitasubramanian T A
Respiration. 1977;34(6):341-7. doi: 10.1159/000193846.
Fatty acid metabolism was investigated in adult male albino rats exposed to hypobaric hypoxia at 25,000 ft simulated altitude for 6 h at 32 degrees C. Oxidation and esterification of palmitic acid-1-14C and de novo lipogenesis from acetate-1-14C were studied. Palmitic acid-1-14C oxidation in liver slices was normal while acetoacetate formation was increased. In vivo esterification of palmitic acid-1-14C to form triglycerides was increased while formation of phosphatidylcholine and phosphatidylethanolamine was observed to decrease. Decreased incorporation into plasma phosphatidylcholine with unaltered total activity in plasma triglycerides was observed. The incorporation of acetate-1-14C was observed to remain unaltered in triglycerides and phospholipids of liver with a similar pattern in the plasma indicating unaltered de novo lipogenesis. There appears to be increased esterification of fatty acids with probably impaired release of triglycerides into plasma while fatty acid biosynthesis remains unaffected.
在32摄氏度下，于模拟海拔25000英尺的低压低氧环境中对成年雄性白化大鼠进行6小时的暴露，研究其脂肪酸代谢。研究了棕榈酸-1-¹⁴C的氧化和酯化以及乙酸-1-¹⁴C的从头脂肪生成。肝切片中棕榈酸-1-¹⁴C的氧化正常，但乙酰乙酸的形成增加。体内棕榈酸-1-¹⁴C酯化形成甘油三酯的过程增加，而磷脂酰胆碱和磷脂酰乙醇胺的形成减少。观察到血浆中磷脂酰胆碱的掺入减少，而血浆甘油三酯的总活性未改变。在肝脏的甘油三酯和磷脂中，乙酸-1-¹⁴C的掺入未改变，血浆中也有类似模式，表明从头脂肪生成未改变。似乎脂肪酸的酯化增加，可能甘油三酯向血浆中的释放受损，而脂肪酸生物合成不受影响。
