Natpratan C, Nantakwang D, Beyrer C, Kunawararak P, Gunhom C, Celentano D D, Nelson K E, Khamboonruang C
Royal Thai Ministry of Public Health Thailand.
Southeast Asian J Trop Med Public Health. 1996 Sep;27(3):457-62.
To determine the feasibility of establishing a cohort of HIV-1 seronegative factory workers for potential HIV vaccine trials, and other HIV preventive interventions, we enroled and followed 499 male and female industrial workers in Lamphun Province, northern Thailand. A baseline demographic and HIV seroprevalence survey was conducted by a mobile team at worker's housing units in Lamphun Province in 1994. Follow-up HIV and syphilis incidence rates were measured 6 months later. The study was voluntary, anonymous, and included HIV pre- and post-test counseling, HIV and syphilis serology, and a self-administered fact sheet. A total of 106 men and 393 women were recruited. The median age was 22 years, and the mean 23.4 years. Educational levels were moderate; 41.9% had some secondary school and 23.6% had completed secondary school. HIV prevalence was 2.4% overall but differed by sex; among men it was 7/106, 6.6%, among women 5/393, 1.3%, OR = 5.49 (95% CI = 1.52, 20.39). Low educational levels were associated with HIV infection, OR = 7.2 (95% CI = 2.2, 23.4). Syphilis prevalence was 3.8%. Follow-up at 6 months was successful for 420/499 subjects, 84.2%, and varied by sex: 73/106 men, 68.9%, returned while 347/393 women, 88.3%, did so, RR = 1.21 (95% CI = 1.07, 1.37). There were 5 incident HIV-1 infections, a rate of 2.1/100 person years. The HIV seroconversion rate differed by sex, but not significantly; it was 4.1/100 person years for men and 1.5/100 person years for women. This population is largely young, female, and at considerable HIV risk. If follow-up could be improved, factory workers in northern Thailand could be an appropriate population in which to mount HIV preventive efficacy studies, including vaccine trials.
为确定建立一组HIV-1血清阴性工厂工人队列以进行潜在的HIV疫苗试验及其他HIV预防干预措施的可行性，我们在泰国北部南奔府招募并随访了499名男女产业工人。1994年，一个流动小组在南奔府工人居住单元进行了基线人口统计学和HIV血清流行率调查。6个月后测量HIV和梅毒的随访发病率。该研究为自愿、匿名性质，包括HIV检测前后咨询、HIV和梅毒血清学检查以及一份自行填写的情况说明书。共招募了106名男性和393名女性。年龄中位数为22岁，平均年龄为23.4岁。教育水平中等；41.9%的人上过一些中学，23.6%的人完成了中学学业。总体HIV流行率为2.4%，但存在性别差异；男性中为7/106，即6.6%，女性中为5/393，即1.3%，比值比（OR）=5.49（95%置信区间[CI]=1.52, 20.39）。低教育水平与HIV感染相关，OR=7.2（95%CI=2.2, 23.4）。梅毒流行率为3.8%。499名受试者中有420名，即84.2%，在6个月时成功进行了随访，且存在性别差异：106名男性中有73名，即68.9%，前来随访，而393名女性中有347名，即88.3%，前来随访，相对危险度（RR）=1.21（95%CI=1.07, 1.37）。有5例新发HIV-1感染，发病率为2.1/100人年。HIV血清转化率存在性别差异，但不显著；男性为4.1/100人年，女性为1.5/100人年。该人群主要为年轻人、女性，且面临相当大的HIV感染风险。如果能改进随访工作，泰国北部的工厂工人可能是开展包括疫苗试验在内的HIV预防效果研究的合适人群。
