Barusrux S, Urwijitaroon Y, Puapairoj C, Romphruk A, Sriwanitchrak P
Blood Transfusion Centre, Faculty of Medicine, Khon Kaen University, Thailand.
J Med Assoc Thai. 1997 Sep;80 Suppl 1:S106-11.
The study was performed to determine the association of seroprevalence of hepatitis C virus (HCV) and Treponema pallidum (T. pallidum) infection among HIV infected first time male blood donors (HIV group) in comparison with the HIV seronegative blood donors (control group) in the Northeast of Thailand (NET). Serum samples were collected from 10,321 first blood donation voluntary male donors. All samples were screened for anti-HIV and anti-HCV by particle agglutination test, and syphilis antibody by RPR. The anti-HIV positive sera were repeated by EIA and confirmed by western blot. The reactive anti-HCV samples were confirmed by EIA whereas reactive syphilis antibody samples were confirmed by TPPA. Fisher's exact test was used for statistical analysis. The prevalence of anti-HIV in first time male donors was 0.70 per cent (72/10,321). The age of HIV group and 10,018 male control group ranged from 17-50 years old. The prevalence of HIV among 21-40 years old age group was significantly higher than the 17-20 years old (p = 0.00003). The 17-20 years old HIV group showed significantly higher sero-prevalence of TPPA (p = 0.003). The 21-30 years old HIV group gave significantly higher sero-prevalence of anti-HCV (p = 0.0008) and TPPA (p = 0.045), but the seroprevalence of anti-HCV and TPPA among the 31-50 year old group were nonsignificantly different (p > 0.05). The concurrence of anti-HCV and TPPA in HIV groups was not found. This result indicated that HIV infection among NET voluntary male blood donors was significantly associated with T. pallidum infection in young adults and the HCV infection in mature adults.
本研究旨在确定泰国东北部首次献血的男性HIV感染者（HIV组）中丙型肝炎病毒（HCV）和梅毒螺旋体（T. pallidum）感染的血清流行率之间的关联，并与HIV血清阴性的献血者（对照组）进行比较。从10321名首次献血的男性自愿者中采集血清样本。所有样本均通过颗粒凝集试验筛查抗HIV和抗HCV，并通过快速血浆反应素试验（RPR）筛查梅毒抗体。抗HIV阳性血清通过酶免疫分析（EIA）重复检测，并通过免疫印迹法确认。反应性抗HCV样本通过EIA确认，而反应性梅毒抗体样本通过梅毒螺旋体颗粒凝集试验（TPPA）确认。采用Fisher精确检验进行统计分析。首次献血男性中抗HIV的流行率为0.70%（72/10321）。HIV组和10018名男性对照组的年龄范围为17至50岁。21至40岁年龄组的HIV流行率显著高于17至20岁年龄组（p = 0.00003）。17至20岁的HIV组TPPA血清流行率显著更高（p = 0.003）。21至30岁的HIV组抗HCV和TPPA血清流行率显著更高（抗HCV，p = 0.0008；TPPA，p = 0.045），但31至50岁年龄组的抗HCV和TPPA血清流行率差异无统计学意义（p > 0.05）。未发现HIV组中抗HCV和TPPA同时存在的情况。该结果表明，泰国东北部自愿献血男性中的HIV感染与年轻人中的梅毒螺旋体感染以及成年人中的HCV感染显著相关。
