Bemelmans N A, Tilanus M A, Cuypers M H, Pinckers A J
Institute of Ophthalmology, University Hospital Nijmegen, The Netherlands.
Am J Ophthalmol. 1997 Jan;123(1):97-102. doi: 10.1016/s0002-9394(14)70998-5.
To determine the extent of pattern-reversal visual evoked potential parameter alteration by epiretinal membranes and to investigate the use of pattern-reversal visual evoked potential in the estimation of macular function in eyes with epiretinal membrane and in the fellow eyes.
In both eyes of 162 patients with epiretinal membrane, 92 of primary and 70 of secondary origin, pattern-reversal visual evoked potentials were recorded. Check sizes of 17', 10', and 7' (minutes of arc) were used. Parameters investigated were N80 and P100 latencies and P100 amplitude.
No significant difference was detected between eyes with epiretinal membrane of primary and secondary origin regarding visual acuity and the pattern-reversal visual evoked potential parameters for the different check sizes. Compared with the fellow eyes, the eyes with epiretinal membrane had a significantly reduced visual acuity, prolonged N80 and P100 latencies, and a reduced P100 amplitude for the different check sizes. Compared with a separate control group (N = 20) with patients 50 to 59 years old, eyes with epiretinal membrane (N = 9) showed the same features as in the total group, but only for the 17' and 10' check sizes. The fellow eyes (N = 9) showed a significant reduction of the P100 amplitude (P < .05) for the pattern sizes of 17' and 10', but no difference in visual acuity or pattern-reversal visual evoked potential latency was found.
In eyes with epiretinal membrane, pattern-reversal visual evoked potential latencies are prolonged, and amplitude is reduced. Relationships between clinical parameters and pattern-reversal visual evoked potential parameters require further study.
确定视网膜前膜引起的图形翻转视觉诱发电位参数改变的程度，并研究图形翻转视觉诱发电位在评估有视网膜前膜的患眼及其对侧眼黄斑功能中的应用。
对162例视网膜前膜患者的双眼进行图形翻转视觉诱发电位记录，其中原发性视网膜前膜92例，继发性视网膜前膜70例。使用17′、10′和7′（角分）的检查刺激大小。研究的参数包括N80和P100潜伏期以及P100波幅。
原发性和继发性视网膜前膜患眼在视力及不同检查刺激大小下的图形翻转视觉诱发电位参数方面未检测到显著差异。与对侧眼相比，有视网膜前膜的患眼视力显著降低，不同检查刺激大小下N80和P100潜伏期延长，P100波幅降低。与一个单独的50至59岁患者对照组（N = 20）相比，有视网膜前膜的患眼（N = 9）表现出与总体组相同的特征，但仅在17′和10′检查刺激大小下。对侧眼（N = 9）在17′和10′图形大小下P100波幅显著降低（P < .05），但在视力或图形翻转视觉诱发电位潜伏期方面未发现差异。
在有视网膜前膜的眼中，图形翻转视觉诱发电位潜伏期延长，波幅降低。临床参数与图形翻转视觉诱发电位参数之间的关系需要进一步研究。
