[Effect of pindolol (Visken) on the size and hemodynamics of the exerimental myocardial infarct in the pig].

In a comparative study the effect of pindolol (Visken, Sandoz) on experimental infarct size and left ventricular function in the pig has been investigated. Pindolol was given 30 min prior to the ligation of the left anterior descending coronary artery and on the following 5 days twice daily in a dosage of 0.05 mg/kg body weight. For morphometric assessment of infarct size the ventricular myocardium was cut into slices and stained with nitro-benztoluene. There is a significant reduction of infarct size (by one third) in the pindolol-treated group as compared to the controls. In addition, deterioration of left ventricular function is less marked in the pindolol-treated group.