苯二氮䓬受体：在中枢神经系统中的显示
Benzodiazepine receptor: demonstration in the central nervous system.
作者信息
Möhler H, Okada T
出版信息
Science. 1977 Nov 25;198(4319):849-51. doi: 10.1126/science.918669.
PMID:918669
Abstract
Diazepam, a potent minor tranquilizer, binds with high affinity to a specific benzodiazepine receptor that occurs exclusively in the central nervous system. The receptor is mainly localized in the synaptic membrane fraction. Binding to the receptor is stereospecific. Competition for the receptor by various benzodiazepines closely parallels their pharmacological potency.
摘要
地西泮是一种强效的弱安定剂，它与一种仅存在于中枢神经系统的特定苯二氮䓬受体具有高亲和力。该受体主要定位于突触膜部分。与受体的结合具有立体特异性。各种苯二氮䓬类药物对该受体的竞争情况与其药理效力密切相关。
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