Claes S, Raeymaekers P, Van den Broeck M, Diependaele S, De bruyn A, Verheyen G, Wils V, Boogaerts A, Tanghe A, Godderis J, Van Broeckhoven C, Cassiman J J
Center for Human Genetics, University of Leuven, Belgium.
J Affect Disord. 1997 May;43(3):195-205. doi: 10.1016/s0165-0327(97)01429-8.
The contribution of genetic factors to the susceptibility for affective disorders has been firmly established. Recent reports found evidence for a susceptibility locus for affective disorders in 2 regions on chromosome 18. We describe 3 large Belgian pedigrees with multiple patients with affective disorders. Both chromosome 18 regions were investigated in the 3 families, using parametric and nonparametric segregation methods. In the pericentromeric region, all evidence was against a disease gene in our families. Also the data obtained for the distal part of 18q, argue against a genetic susceptibility factor in our sample.
