使用经典病例对照研究和单倍型相对风险法，未发现血清素/半胱氨酸311多巴胺D2受体分子变体与精神分裂症之间存在关联。
No association of the Ser/Cys311 DRD2 molecular variant with schizophrenia using a classical case control study and the haplotype relative risk.
作者信息
Verga M, Macciardi F, Pedrini S, Cohen S, Smeraldi E
机构信息
Istituto Scientifico H. San Raffaele, Department of Neuropsychiatric Science, University of Milan, Italy.
出版信息
Schizophr Res. 1997 May 24;25(2):117-21. doi: 10.1016/S0920-9964(97)00013-3.
Arinami et al. (1994) reported an association between the Ser311/Cys311 variant of the DRD2 gene and schizophrenia in a Japanese population. We did not find statistically significant differences in the distribution of the allele frequencies between schizophrenics (103) and controls (97) in a case-control sample (chi 2 = 2.07; p = 0.150) or in 64 nuclear families with the haplotype relative risk (HRR) design (chi 2 = 0.13; p = 0.718). Our results seem to exclude a main involvement of this variant of the dopamine D2 receptor gene in the etiopathogenesis of schizophrenia.
有波等（1994年）报告称，在日本人群中，DRD2基因的Ser311/Cys311变体与精神分裂症之间存在关联。在一个病例对照样本中（χ² = 2.07；p = 0.150），我们未发现精神分裂症患者（103例）和对照组（97例）之间等位基因频率分布存在统计学上的显著差异；在采用单倍型相对风险（HRR）设计的64个核心家庭中（χ² = 0.13；p = 0.718）也是如此。我们的结果似乎排除了多巴胺D2受体基因的这一变体在精神分裂症病因学中起主要作用的可能性。
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