Maury E, Ioos V, Lepecq B, Guidet B, Offenstadt G
Intensive Care Unit, Hôpital Saint Antoine, Paris, France.
Chest. 1997 Jun;111(6):1766-7. doi: 10.1378/chest.111.6.1766.
Lactic acidosis previously has been reported during treatment of asthma with beta-2 agonists. However, this metabolic disturbance never had any clinical consequence. We report a case of a patient with asthma in whom beta-2 agonist administration increased dyspnea by metabolic acidosis due to a sharp increase in lactate levels (hyperlactatemia) and led to inappropriate intensification of bronchodilator therapy.
先前已有报道称，在使用β-2激动剂治疗哮喘期间会发生乳酸酸中毒。然而，这种代谢紊乱从未产生过任何临床后果。我们报告了一例哮喘患者，该患者在使用β-2激动剂后，由于乳酸水平急剧升高（高乳酸血症）导致代谢性酸中毒，从而加重了呼吸困难，并导致支气管扩张剂治疗不当强化。
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