内侧视前区的轴突保留性损伤会阻断雌性性行为。

Axon sparing lesions of the medial preoptic area block female sexual behavior.

作者信息

Veney S L, Rissman E F

机构信息

Department of Biology, University of Virginia, Charlottesville 22903, USA.

出版信息

Brain Res. 1997 May 9;756(1-2):273-7. doi: 10.1016/s0006-8993(97)00161-3.

DOI:10.1016/s0006-8993(97)00161-3

PMID:9187342

Abstract

The role of the medial preoptic area (mPOA) in regulating female musk shrew sexual behavior was assessed with excitatory neurotoxin, N-methyl-D-aspartate (NMDA) lesions. Ovariectomized, testosterone-implanted females that received lesions in the mPOA were statistically less likely to show complete sex behavior as compared to controls. These data suggest that the mPOA plays an activational role in testosterone-induced female sexual behavior.

摘要

采用兴奋性神经毒素N-甲基-D-天冬氨酸（NMDA）损伤法，评估内侧视前区（mPOA）在调节雌性麝鼩性行为中的作用。与对照组相比，接受mPOA损伤的去卵巢并植入睾酮的雌性，在统计学上表现出完全性行为的可能性较小。这些数据表明，mPOA在睾酮诱导的雌性性行为中起激活作用。