Stokol T, Randolph J F, Nachbar S, Rodi C, Barr S C
Department of Pathology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853-6401, USA.
J Am Vet Med Assoc. 1997 Jun 15;210(12):1753-6.
Bone marrow toxicosis was detected in a dog and cat following albendazole administration. Both animals were admitted with pancytopenia. In the dog, pancytopenia was attributed to severe panmarrow hypoplasia, whereas the cat had hypoplasia of erythroid and megakaryocytic series, but with a left-shifted granulocytic hyperplasia. Results of cytologic examination of bone marrow from both animals were compatible with acute injury. Both animals had been treated with albendazole for giardiasis prior to the onset of clinical signs. Bone marrow toxicosis was attributed to albendazole administration for the following reasons: this was the only or most recent drug administered, other causes of bone marrow toxicosis were not found, and both animals recovered rapidly with supportive care that consisted of fluid and antibiotic administration. Albendazole induced toxicosis appeared to be dose related in the dog and idiosyncratic in the cat. On the basis of the findings in this report, there is a potential for the development of albendazole induced bone marrow toxicosis in dogs and cats; therefore, veterinarians should exercise caution when using this drug.
在给一只狗和一只猫服用阿苯达唑后检测到骨髓中毒。两只动物均因全血细胞减少症入院。在狗身上，全血细胞减少症归因于严重的全骨髓发育不全，而猫则出现红系和巨核细胞系发育不全，但粒细胞增生左移。两只动物骨髓的细胞学检查结果均与急性损伤相符。两只动物在出现临床症状之前均已接受阿苯达唑治疗贾第虫病。骨髓中毒归因于阿苯达唑给药，原因如下：这是唯一或最近使用的药物，未发现骨髓中毒的其他原因，并且两只动物通过包括补液和使用抗生素在内的支持性护理迅速康复。阿苯达唑诱导的中毒在狗身上似乎与剂量有关，在猫身上则是特异质性的。根据本报告中的发现，狗和猫有发生阿苯达唑诱导的骨髓中毒的可能性；因此，兽医在使用这种药物时应谨慎。
