Fuentealba C, Guest S, Haywood S, Horney B
Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Prince Edward Island.
Can Vet J. 1997 Jun;38(6):365-73.
The aims of this study were to characterize the histological changes observed in 34 accessioned cases of canine chronic hepatitis and to correlate these changes with the clinical pathological data. Cases of chronic hepatitis were subdivided into 6 categories: chronic active hepatitis (10/34), chronic persistent hepatitis (7/32), chronic cholestatic hepatitis (6/34), fibrosing hepatitis with cirrhosis (3/34), chronic cholangiohepatitis (3/34), and miscellaneous secondary hepatitis (5/34). Iron accumulation was a consistent finding in all livers examined. Although all cases of chronic hepatitis had elevated liver enzymes, no correlation was detected between biochemical parameters and the severity of morphologic changes. Similarly, no correlation was detected between rhodanine staining for copper and morphologic or biochemical indicators of cholestasis. However, presence of copper correlated well with reticulo-fibrosis (r = 0.8) and bile duct hyperplasia, suggesting that changes in the hemodynamics of the hepatic acini due to fibrosis could influence storage of copper.
本研究的目的是描述在34例登记的犬慢性肝炎病例中观察到的组织学变化，并将这些变化与临床病理数据相关联。慢性肝炎病例被细分为6类：慢性活动性肝炎（10/34）、慢性持续性肝炎（7/32）、慢性胆汁淤积性肝炎（6/34）、伴有肝硬化的纤维化性肝炎（3/34）、慢性胆管性肝炎（3/34）和其他继发性肝炎（5/34）。在所检查的所有肝脏中均发现有铁蓄积。虽然所有慢性肝炎病例的肝酶均升高，但未检测到生化参数与形态学变化严重程度之间的相关性。同样，罗丹宁铜染色与胆汁淤积的形态学或生化指标之间也未检测到相关性。然而，铜的存在与网状纤维化（r = 0.8）和胆管增生密切相关，提示纤维化导致的肝腺泡血流动力学变化可能影响铜的储存。
