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健康人体大脑去甲肾上腺素溢出及其与肌肉交感神经活动的关系。

Cerebral noradrenaline spillover and its relation to muscle sympathetic nervous activity in healthy human subjects.

作者信息

Lambert G W, Thompson J M, Turner A G, Cox H S, Wilkinson D, Vaz M, Kalff V, Kelly M J, Jennings G L, Esler M D

机构信息

Human Autonomic Function Laboratory, Baker Medical Research Institute, Prahran, Vic., Australia.

出版信息

J Auton Nerv Syst. 1997 May 12;64(1):57-64. doi: 10.1016/s0165-1838(97)00018-0.

Abstract

Studies using internal jugular vein blood sampling in human subjects have demonstrated the release of noradrenaline from the brain and have provided a link between central nervous system noradrenergic neuronal activity and renal, cardiac and total body sympathetic activity. The aim of this study was to further categorise the dependence of regional sympathetic nervous function on central nervous system noradrenergic neuronal processes by combining measures of internal jugular venous noradrenaline spillover, as an indicator of brain noradrenaline release, and cerebral blood flow scans with measures of the overall integrated neuronal firing rate for the body as a whole, the spillover of noradrenaline into the coronary sinus and with measurements of resting muscle sympathetic nerve activity. Positive veno-arterial plasma noradrenaline gradients were found across the brain, with the plasma concentration being 17 +/- 3% (p < 0.01) greater in the internal jugular vein. Linear regression analysis revealed a significant relationship between the degree of muscle sympathetic nerve activity and the spillover of noradrenaline from subcortical brain regions (y = 0.1 x + 16.0; r = 0.81, p < 0.02). The rate of spillover of noradrenaline for the body as a whole also bore a significant association with the rate of subcortical noradrenaline spillover (y = 0.01x + 2.33; r = 0.71, p < 0.05). Cortical noradrenaline spillover was not related to any of the sympathetic nervous system parameters measured in this study. The demonstration of a direct relationship between the rate of peroneal nerve firing and the spillover of noradrenaline from subcortical brain regions provides further support for the concept of central nervous system noradrenergic cell groups behaving in a sympathoexcitatory role.

摘要

在人体受试者中使用颈内静脉采血的研究已经证明大脑会释放去甲肾上腺素,并建立了中枢神经系统去甲肾上腺素能神经元活动与肾脏、心脏及全身交感神经活动之间的联系。本研究的目的是通过结合颈内静脉去甲肾上腺素溢出量(作为脑去甲肾上腺素释放的指标)、脑血流扫描以及全身整体综合神经元放电率的测量、去甲肾上腺素向冠状窦的溢出量测量和静息肌肉交感神经活动的测量,进一步分类区域交感神经功能对中枢神经系统去甲肾上腺素能神经元过程的依赖性。发现大脑中存在正向的静脉 - 动脉血浆去甲肾上腺素梯度,颈内静脉中的血浆浓度高17±3%(p < 0.01)。线性回归分析显示肌肉交感神经活动程度与来自皮质下脑区的去甲肾上腺素溢出量之间存在显著关系(y = 0.1x + 16.0;r = 0.81,p < 0.02)。全身去甲肾上腺素的溢出率也与皮质下去甲肾上腺素溢出率显著相关(y = 0.01x + 2.33;r = 0.71,p < 0.05)。皮质去甲肾上腺素溢出与本研究中测量的任何交感神经系统参数均无关联。腓总神经放电率与皮质下脑区去甲肾上腺素溢出量之间直接关系的证明,为中枢神经系统去甲肾上腺素能细胞群发挥交感兴奋作用的概念提供了进一步支持。

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