鉴定人巨细胞病毒编码的一种趋化因子受体作为HIV-1进入的辅助因子。

Identification of a chemokine receptor encoded by human cytomegalovirus as a cofactor for HIV-1 entry.

作者信息

Pleskoff O, Tréboute C, Brelot A, Heveker N, Seman M, Alizon M

机构信息

Inserm U.332, Institut Cochin de Génétique Moléculaire, 22 rue Méchain, 75014 Paris, France.

出版信息

Science. 1997 Jun 20;276(5320):1874-8. doi: 10.1126/science.276.5320.1874.

DOI:10.1126/science.276.5320.1874

PMID:9188536

Abstract

The human cytomegalovirus encodes a beta-chemokine receptor (US28) that is distantly related to the human chemokine receptors CCR5 and CXCR4, which also serve as cofactors for the entry into cells of human immunodeficiency virus-type 1 (HIV-1). Like CCR5, US28 allowed infection of CD4-positive human cell lines by primary isolates of HIV-1 and HIV-2, as well as fusion of these cell lines with cells expressing the viral envelope proteins. In addition, US28 mediated infection by cell line-adapted HIV-1 for which CXCR4 was an entry cofactor.

摘要

人类巨细胞病毒编码一种β趋化因子受体（US28），它与人类趋化因子受体CCR5和CXCR4有较远的亲缘关系，而CCR5和CXCR4也是人类免疫缺陷病毒1型（HIV-1）进入细胞的辅助因子。与CCR5一样，US28允许HIV-1和HIV-2的原始分离株感染CD4阳性人类细胞系，以及这些细胞系与表达病毒包膜蛋白的细胞融合。此外，US28介导了细胞系适应性HIV-1的感染，对于这种病毒，CXCR4是其进入细胞的辅助因子。