D'Agostino B, Matera M G, Amorena M, Marabese I, Lucisano A, Rossi F
Institute of Pharmacology and Toxicology, Faculty of Medicine and Surgery, 2nd University of Naples, Italy.
Life Sci. 1997;60(24):PL 353-7. doi: 10.1016/s0024-3205(97)00240-3.
Nitric oxide (NO) has been cited to play an important regulatory role in airway function. Moreover, the NO synthase expression in models of inflammation is documented. The aim of this study was to investigate, in vitro, the NO modulation of cholinergic responses in sham-sensitized and ovalbumin-sensitized guinea pig trachea by using L-arginine (L-ARG), a precursor of NO synthesis, and L-Ng-nitro-arginine-methyl-ester (L-NAME), an inhibitor of NO synthase. Our results showed that NO's ability to modulate cholinergic responses in ovalbumin-sensitized guinea pig trachea is lost. Indeed L-ARG and L-NAME modify acetylcholine sensitivity in sham-sensitized guinea pig but not in ovalbumin-sensitized guinea pig.
一氧化氮（NO）被认为在气道功能中发挥重要的调节作用。此外，炎症模型中一氧化氮合酶的表达也有记录。本研究的目的是在体外，通过使用L-精氨酸（L-ARG，NO合成的前体）和L-Ng-硝基-精氨酸甲酯（L-NAME，一氧化氮合酶抑制剂），研究NO对假致敏和卵清蛋白致敏豚鼠气管胆碱能反应的调节作用。我们的结果表明，NO调节卵清蛋白致敏豚鼠气管胆碱能反应的能力丧失。事实上，L-ARG和L-NAME改变了假致敏豚鼠对乙酰胆碱的敏感性，但在卵清蛋白致敏豚鼠中却没有。
