Marshall E F, Perry R H, Perry E K, Piggott M A, Thompson P, Jaros E, Burn D J
Department of Psychiatry, University of Newcastle upon Tyne, UK.
Acta Neurol Scand. 1997 May;95(5):287-92. doi: 10.1111/j.1600-0404.1997.tb00212.x.
Neurochemical analyses of post-mortem brain from cases of corticobasal degeneration are extremely rare although nearly 100 cases have been reported in the literature. We detail findings of neurotransmitter derangement in the basal ganglia of a case of neuropathologically confirmed corticobasal degeneration, who presented with dementia. The implications of severe neuronal loss in the substantia nigra and extremely low levels of dopamine and its metabolites in the striatum are considered in relation to the absence of an intrinsic extrapyramidal syndrome.
尽管文献中已报道了近100例皮质基底节变性病例，但对其死后大脑进行神经化学分析的情况极为罕见。我们详细阐述了一例经神经病理学确诊为皮质基底节变性且伴有痴呆症状患者基底神经节中神经递质紊乱的研究结果。结合无内在锥体外系综合征的情况，我们考虑了黑质中严重神经元丢失以及纹状体中多巴胺及其代谢产物极低水平的影响。
