Bjaalie J G, Sudbø J, Brodal P
Department of Anatomy, University of Oslo, Norway.
Neuroreport. 1997 May 6;8(7):1651-5. doi: 10.1097/00001756-199705060-00019.
We investigated whether terminal fibres in the pontine nuclei are arranged in a lamellar pattern like that demonstrated earlier for pontocerebellar neurones. Following tracer injections in visual and parietal cortices and subsequent computer-based 3-D analysis, we found that labelled corticopontine terminal fibres form numerous sharply delimited aggregates of variable shape. Several of the aggregates are cylindroids (diameter 200-300 microns, length 1-3 mm). The aggregates are confined to a lamellar subspace, the position of which depends on the anteroposterior location of the cortical injections. These findings suggest that the cerebroponto-cerebellar system may be organized according to fairly simple, topographical rules. We discuss the implications of our results in relation to the development of corticopontine topographical organization.
我们研究了脑桥核中的终末纤维是否像先前在脑桥小脑神经元中所证实的那样呈层状排列。在视觉和顶叶皮质注射示踪剂并随后进行基于计算机的三维分析后，我们发现标记的皮质脑桥终末纤维形成了许多形状各异、界限分明的聚集体。其中一些聚集体呈柱状体（直径200 - 300微米，长度1 - 3毫米）。这些聚集体局限于一个层状子空间，其位置取决于皮质注射的前后位置。这些发现表明，脑桥小脑系统可能是按照相当简单的拓扑规则组织起来的。我们讨论了我们的结果对于皮质脑桥拓扑组织发育的意义。
