Kuz'mina L P, Bezrukavnikova L M, Arkhipova O G, Kasparov A A
Med Tr Prom Ekol. 1997(4):15-8.
The work was aimed to study relationship of monooxygenase system and lipid peroxidation in experiments and in clinical group. The examinees were workers engaged into graphite ware production and exposed to low fibrogenic dust of coke and graphite with carcinogens (including 3,4-benzpyrene). The experimental data and examination materials prove the carcinogens to alter seriously those systems. Long stimulation of monooxygenase system and activation of lipid peroxidation could result in more intensive carcinogenic effects of polycyclic aromatic hydrocarbons being a component of coal pitch.
这项工作旨在研究实验和临床组中，单加氧酶系统与脂质过氧化之间的关系。研究对象为从事石墨制品生产的工人，他们接触含有致癌物（包括3,4-苯并芘）的焦炭和石墨低纤维生成性粉尘。实验数据和检查材料证明，致癌物会严重改变这些系统。单加氧酶系统的长期刺激和脂质过氧化的激活，可能会导致煤焦油成分多环芳烃的致癌作用更加强烈。
