[The role of calcium antagonists on coronary artery spasm and prevention of restenosis after angioplasty].

Classification, mechanism of action, hemodynamic and electrophysiological effects of calcium antagonists also structure of L-type calcium channel (cell receptor for this group of drugs) have been presented. Current views about the role of calcium channel antagonists in treatment of vasospastic angina pectoris, in particular Prinzmetal's angina, have been discussed. The use of calcium antagonists for the prevention of coronary restenosis after successful percutaneous transluminal coronary angioplasty have been analysed. Beneficial effects of calcium channel blockers (diltiazem 180 mg per day and verapamil 480 mg per day) for the prevention of restenosis after coronary angioplasty in a group of patients with stable angina pectoris have been demonstrated. Future directions in the trials on the calcium antagonists were been also presented.