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赛米利疱疹病毒永生化的人类T细胞支持1型和2型人类免疫缺陷病毒的长期、高滴度复制。

Herpesvirus saimiri-immortalized human T-cells support long-term, high titred replication of human immunodeficiency virus types 1 and 2.

作者信息

Vella C, Fickenscher H, Atkins C, Penny M, Daniels R

机构信息

National Institute for Medical Research, London, UK.

出版信息

J Gen Virol. 1997 Jun;78 ( Pt 6):1405-9. doi: 10.1099/0022-1317-78-6-1405.

Abstract

Herpesvirus saimiri strain C488 transforms human CD4+ T-lymphocytes to continuous interleukin-2-dependent growth. Unlike human T-cell lines derived from tumours or those transformed by human T-lymphotropic virus 1, herpesvirus saimiri-immortalized T-cells (HVS T-cells) retain many functions of primary activated T-lymphocytes. We have characterized the course of human immunodeficiency virus types 1 and 2 (HIV-1/-2) infection in three HVS T-cell lines. Our results confirm that HVS T-cells are highly permissive to both HIV-1/-2 prototype viruses and to poorly replicating HIV-2 strains of restricted cell tropism. However, the infection was persistently productive for up to 5 months. The down-regulation of surface CD4 molecules was delayed and virus yields significantly exceeded those obtained in T-cell lines.

摘要

赛氏疱疹病毒C488株可将人CD4 + T淋巴细胞转化为持续依赖白细胞介素-2的生长状态。与源自肿瘤的人T细胞系或由人嗜T淋巴细胞病毒1转化的细胞系不同,赛氏疱疹病毒永生化T细胞(HVS T细胞)保留了原代活化T淋巴细胞的许多功能。我们已对三个HVS T细胞系中1型和2型人类免疫缺陷病毒(HIV-1/-2)的感染过程进行了表征。我们的结果证实,HVS T细胞对HIV-1/-2原型病毒以及细胞嗜性受限的低复制HIV-2毒株都具有高度易感性。然而,感染可持续产生病毒长达5个月。表面CD4分子的下调延迟,且病毒产量显著超过在T细胞系中获得的产量。

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