猴疱疹病毒转化的人CD4 + T细胞系：用于分析人免疫缺陷病毒特异性细胞毒性CD8 + T淋巴细胞活性的高效靶细胞系统。
Herpesvirus saimiri-transformed human CD4+ T-cell lines: an efficient target cell system for the analysis of human immunodeficiency virus-specific cytotoxic CD8+ T-lymphocyte activity.
作者信息
Bauer M, Lucchiari-Hartz M, Fickenscher H, Eichmann K, McKeating J, Meyerhans A
机构信息
Abteilung Virologie, Institut für Medizinische Mikrobiologie und Hygiene, Universität Freiburg, Germany.
出版信息
J Virol. 1998 Feb;72(2):1627-31. doi: 10.1128/JVI.72.2.1627-1631.1998.
Abstract
Herpesvirus saimiri growth-transformed human CD4+ T lymphocytes were examined for their suitability as a target cell system for investigating human immunodeficiency virus (HIV)-specific HLA class I-restricted cytotoxic T-cell activity. Besides CD4, they express the chemokine receptors CCR5 and CXCR4, the common coreceptors of HIV. They are infectible by a range of HIV strains, including primary isolates, becoming efficient targets for CD8-positive HIV-specific cytotoxic T lymphocytes.
摘要
对感染了猴疱疹病毒并发生生长转化的人CD4+ T淋巴细胞进行了检测，以评估其作为研究人类免疫缺陷病毒（HIV）特异性HLA I类限制性细胞毒性T细胞活性的靶细胞系统的适用性。除了CD4，它们还表达趋化因子受体CCR5和CXCR4，即HIV的共同共受体。它们可被一系列HIV毒株感染，包括原代分离株，从而成为CD8阳性HIV特异性细胞毒性T淋巴细胞的有效靶标。
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