Toker A, Cantley L C
Boston Biomedical Research Institute, Massachusetts 02114, USA.
Nature. 1997 Jun 12;387(6634):673-6. doi: 10.1038/42648.
When a stimulatory agonist molecule binds at the exterior of the cell membrane, a second messenger transduces the signal to the interior of the cell. Second messengers can be derived from phospholipids in the membrane by the action of the enzymes phospholipase C or phosphoinositide-3-OH kinase (PI(3)K). PI(3)K is a key player in many cellular responses, including the movement of organelle membranes, shape alteration through rearrangement of cytoskeletal actin, transformation and chemotaxis. But how PI(3)K mediates these responses is only now becoming clear.
当刺激性激动剂分子在细胞膜外部结合时，第二信使将信号转导至细胞内部。第二信使可通过磷脂酶C或磷酸肌醇-3-OH激酶（PI(3)K）的作用从膜中的磷脂衍生而来。PI(3)K在许多细胞反应中起关键作用，包括细胞器膜的移动、通过细胞骨架肌动蛋白重排改变形状、转化和趋化作用。但PI(3)K如何介导这些反应目前才逐渐明晰。
