Salganik R I, Manankova N M, Semenova L A
Vopr Med Khim. 1977 Jul-Aug;23(4):468-73.
An inductor of microsomal enzymes 9-acetate-16alpha-isothiocyanogen pregnenolone (ATCP), administered into rats within 5 days after termination of feeding with an atherogenic diet, caused normalization of cholesterol content in blood, of beta-lipoproteins spectrum as well as the structure of liver cells. At the same time, in animals, which were not treated with ATCP, high level of cholesterol was maintained in blood serum; reducing smooth endoplasmic reticulum and a decrease in content of glycogen in hepatocytes were also observed. Enzymatic oxidation of cholesterol into 7alpha-hydroxycholesterol, distinctly stimulated by ATCP, appears to be the cause of increased elimination of cholesterol from the organism. ATCP might be used as a drug decreasing the content of cholesterol in blood of patients with hypercholesterolemia.
微粒体酶9-乙酸盐-16α-异硫氰基孕烯醇酮（ATCP），在致动脉粥样硬化饮食喂养终止后的5天内给予大鼠，可使血液中胆固醇含量、β-脂蛋白谱以及肝细胞结构恢复正常。与此同时，未用ATCP治疗的动物血清中胆固醇水平维持在较高水平；还观察到肝细胞中滑面内质网减少和糖原含量降低。ATCP明显刺激胆固醇酶促氧化为7α-羟基胆固醇，这似乎是机体胆固醇清除增加的原因。ATCP可用作降低高胆固醇血症患者血液中胆固醇含量的药物。
