Gorkin V Z, Zeinalov T A, Kudriashov Iu B, Riazanov V M
Vopr Med Khim. 1977 Jul-Aug;23(4):508-15.
Inhibition of monoamine oxidase (substrates tyramine or serotonin) with simultaneous appearance of diamine oxidase (substrates histamine or putrescine) and distinct increase in AMP-deaminating activities were found after total body X-ray irradiation (700 r) of white mice or rats in mitochondrial fractions isolated from their liver and intestines. These impairments in deamination of nitrogenous compounds in liver mitochondria of guinea pigs, which are must less radioresistant as compared with mice or rats, were noted after the irradiation at a dose 300 r, but in the liver mitochondria of mongolian gerbyls (Mariones unguiculatus), which are highly radioresistant, the irradiation even at a dose 1500 r did not cause appearance either of histamine or of AMP-deaminating activities while the decrease in the monoamine oxidase activity was not statistically significant. Feeding to the mice the grasses, which comprize the fodder of mongolian gerbyls under natural conditions, increased radioresistance of the animals and prevented at the same time appearance in the mitochondrial fractions of liver and intestines of those impairments in deamination of nitrogenous compounds which accompanied development of irradiation injuries.
在对白色小鼠或大鼠进行全身X射线照射（700伦琴）后，从它们的肝脏和肠道分离出线粒体部分，发现单胺氧化酶（底物为酪胺或5-羟色胺）受到抑制，同时二胺氧化酶（底物为组胺或腐胺）出现，且AMP脱氨基活性明显增加。豚鼠肝脏线粒体中含氮化合物脱氨基功能的这些损伤，与小鼠或大鼠相比，其辐射抗性要小得多，在300伦琴的照射剂量后就已出现，但在高度抗辐射的蒙古沙鼠（长爪沙鼠）的肝脏线粒体中，即使照射剂量达到1500伦琴，也未引起组胺或AMP脱氨基活性的出现，而单胺氧化酶活性的降低在统计学上并不显著。给小鼠喂食在自然条件下构成蒙古沙鼠食物的草，可提高动物的辐射抗性，同时防止肝脏和肠道线粒体部分出现伴随辐射损伤发展的含氮化合物脱氨基功能的那些损伤。
