Kapur S, Jones C, DaSilva J, Wilson A, Houle S
Schizophrenia Division, Clarke Institute of Psychiatry, University of Toronto, Ontario, Canada.
Nucl Med Commun. 1997 May;18(5):395-9. doi: 10.1097/00006231-199705000-00002.
Position emission tomography (PET) imaging of 5-HT2 receptors can be potentially very useful in investigating neuropsychiatric disorders and their pharmacological treatments. [18F]-setoperone, a PET radio-ligand, has been shown to be useful for the delineation of 5-HT2 receptors in the cortex. However, there is no available data regarding the scan-rescan reliability of this technique. The purpose of this study was to assess the reliability of the [18F]-setoperone PET technique for assessing the binding potential (Bmax/ Kd) for 5-HT2 receptors. Ten healthy subjects had two [18F]-setoperone PET scans on two separate occasions 6-21 days apart. The average difference in the 5-HT2 binding potential (BP) as measured on the two occasions in the prefrontal, temporal, parietal and occipital region was between 5 and 7%. Thus 5-HT2 BP can be measured with a high reliability using a non-invasive technique that uses the cerebellum as a reference region. A power analysis based on the reliability data suggests that this technique can be used to detect within-subject differences of 10% or more, and between-group differences of 25% or more, with a reasonable number of subjects. It is concluded that [18F]-setoperone can be routinely produced and reliably used for the PET imaging of 5-HT2 receptors in clinical situations.
5-羟色胺2（5-HT2）受体的正电子发射断层扫描（PET）成像在研究神经精神疾病及其药物治疗方面可能非常有用。[18F] - 司替戊醇，一种PET放射性配体，已被证明可用于描绘皮质中的5-HT2受体。然而，关于该技术的扫描 - 重扫描可靠性尚无可用数据。本研究的目的是评估[18F] - 司替戊醇PET技术评估5-HT2受体结合潜力（Bmax / Kd）的可靠性。十名健康受试者在相隔6 - 21天的两个不同时间进行了两次[18F] - 司替戊醇PET扫描。在额叶、颞叶、顶叶和枕叶区域两次测量的5-HT2结合潜力（BP）的平均差异在5%至7%之间。因此，使用以小脑作为参考区域的非侵入性技术可以高度可靠地测量5-HT2 BP。基于可靠性数据的功效分析表明，该技术可用于检测受试者内10%或更多的差异，以及组间25%或更多的差异，所需受试者数量合理。结论是，[18F] - 司替戊醇可以常规生产并可靠地用于临床情况下5-HT2受体的PET成像。
