Quercia R A, Zhang J, Fan C, Chow M S
Department of Pharmacy Services, Hartford Hospital, CT 06102, USA.
Am J Health Syst Pharm. 1997 Jun 15;54(12):1404-6. doi: 10.1093/ajhp/54.12.1404.
The stability of granisetron 0.2 mg/mL (as the hydrochloride salt) in an extemporaneously prepared oral liquid was studied. Twelve 1-mg granisetron tablets were pulverized and suspended in 30 mL of distilled water. This mixture was then diluted with cherry syrup to produce a 60-mL oral liquid with a granisetron concentration of 0.2 mg/mL. Half of the preparation was stored at 5 degrees C, and half was stored at 24 degrees C. Samples were taken on days 0, 1, 2, 3, 4, 6, 8, 10, 12, and 14 and assayed by high-performance liquid chromatography. There was no change in the liquid's color, consistency, or pH, and the concentrations of granisetron ranged from 97% to 104% of initial concentration during the 14 days at 5 and 24 degrees C. Granisetron 0.2 mg/mL (as the hydrochloride salt) in an extemporaneously prepared oral liquid was stable for up to 14 days.
对临时配制的口服液中0.2 mg/mL（以盐酸盐形式）的格拉司琼稳定性进行了研究。将12片1 mg的格拉司琼片剂研碎并悬浮于30 mL蒸馏水中。然后用樱桃糖浆将该混合物稀释，制成60 mL格拉司琼浓度为0.2 mg/mL的口服液。制剂的一半储存在5℃，另一半储存在24℃。在第0、1、2、3、4、6、8、10、12和14天取样，并用高效液相色谱法进行测定。液体的颜色、稠度或pH值没有变化，在5℃和24℃下的14天内，格拉司琼的浓度为初始浓度的97%至104%。临时配制的口服液中0.2 mg/mL（以盐酸盐形式）的格拉司琼在长达14天内是稳定的。
