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Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine.

作者信息

Crystal R G, Hirschowitz E, Lieberman M, Daly J, Kazam E, Henschke C, Yankelevitz D, Kemeny N, Silverstein R, Ohwada A, Russi T, Mastrangeli A, Sanders A, Cooke J, Harvey B G

机构信息

Rockefeller University Hospital, New York, New York 10021, USA.

出版信息

Hum Gene Ther. 1997 May 20;8(8):985-1001. doi: 10.1089/hum.1997.8.8-985.

DOI:10.1089/hum.1997.8.8-985
PMID:9195221
Abstract
摘要

相似文献

1
Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine.一项关于将携带大肠杆菌胞嘧啶脱氨酶基因的复制缺陷型腺病毒载体直接注射至肝转移性结肠癌，并联合口服前体药物5-氟胞嘧啶的I期研究。
Hum Gene Ther. 1997 May 20;8(8):985-1001. doi: 10.1089/hum.1997.8.8-985.
2
Regional 'pro-drug' gene therapy: intravenous administration of an adenoviral vector expressing the E. coli cytosine deaminase gene and systemic administration of 5-fluorocytosine suppresses growth of hepatic metastasis of colon carcinoma.区域性“前药”基因治疗：静脉注射表达大肠杆菌胞嘧啶脱氨酶基因的腺病毒载体并全身给予5-氟胞嘧啶可抑制结肠癌肝转移灶的生长。
Gene Ther. 1998 Apr;5(4):507-13. doi: 10.1038/sj.gt.3300611.
3
Enzyme/prodrug gene therapy for human colon cancer cells using adenovirus-mediated transfer of the Escherichia coli cytosine deaminase gene driven by a CAG promoter associated with 5-fluorocytosine administration.使用腺病毒介导的由与5-氟胞嘧啶给药相关的CAG启动子驱动的大肠杆菌胞嘧啶脱氨酶基因转移对人结肠癌细胞进行酶/前药基因治疗。
J Exp Clin Cancer Res. 2000 Mar;19(1):75-80.
4
Adenovirus-mediated GM-CSF gene and cytosine deaminase gene transfer followed by 5-fluorocytosine administration elicit more potent antitumor response in tumor-bearing mice.腺病毒介导的粒细胞-巨噬细胞集落刺激因子基因和胞嘧啶脱氨酶基因转移，随后给予5-氟胞嘧啶，在荷瘤小鼠中引发更强的抗肿瘤反应。
Gene Ther. 1998 Aug;5(8):1130-6. doi: 10.1038/sj.gt.3300727.
5
Systemic administration of a recombinant vaccinia virus expressing the cytosine deaminase gene and subsequent treatment with 5-fluorocytosine leads to tumor-specific gene expression and prolongation of survival in mice.全身性给予表达胞嘧啶脱氨酶基因的重组痘苗病毒，随后用5-氟胞嘧啶进行治疗，可导致肿瘤特异性基因表达并延长小鼠的生存期。
Cancer Res. 1999 Jul 15;59(14):3396-403.
6
Adenovirus mediated cytosine deaminase gene transduction and 5-fluorocytosine therapy sensitizes mouse prostate cancer cells to irradiation.腺病毒介导的胞嘧啶脱氨酶基因转导及5-氟胞嘧啶治疗使小鼠前列腺癌细胞对辐射敏感。
J Urol. 2000 Dec;164(6):2173-7.
7
Cytosine deaminase/5-fluorocytosine-based vaccination against liver tumors: evidence of distant bystander effect.基于胞嘧啶脱氨酶/5-氟胞嘧啶的肝癌疫苗接种：远处旁观者效应的证据。
J Natl Cancer Inst. 1999 Dec 1;91(23):2014-9. doi: 10.1093/jnci/91.23.2014.
8
Regional delivery of an adenovirus vector containing the Escherichia coli cytosine deaminase gene to provide local activation of 5-fluorocytosine to suppress the growth of colon carcinoma metastatic to liver.携带大肠杆菌胞嘧啶脱氨酶基因的腺病毒载体的区域递送，以实现5-氟胞嘧啶的局部激活，从而抑制转移至肝脏的结肠癌生长。
Hum Gene Ther. 1996 Aug 20;7(13):1567-76. doi: 10.1089/hum.1996.7.13-1567.
9
The potential of 5-fluorocytosine/cytosine deaminase enzyme prodrug gene therapy in an intrahepatic colon cancer model.5-氟胞嘧啶/胞嘧啶脱氨酶前药基因疗法在肝内结肠癌模型中的潜力。
Gene Ther. 2002 Jul;9(13):844-9. doi: 10.1038/sj.gt.3301706.
10
Combined suicide gene therapy for human colon cancer cells using adenovirus-mediated transfer of escherichia coli cytosine deaminase gene and Escherichia coli uracil phosphoribosyltransferase gene with 5-fluorocytosine.利用腺病毒介导的大肠杆菌胞嘧啶脱氨酶基因和大肠杆菌尿嘧啶磷酸核糖转移酶基因与5-氟胞嘧啶联合进行人结肠癌细胞的自杀基因治疗
Cancer Gene Ther. 2000 Jul;7(7):1015-22. doi: 10.1038/sj.cgt.7700189.

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PLoS One. 2014 Apr 10;9(4):e94050. doi: 10.1371/journal.pone.0094050. eCollection 2014.
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