新型促胃肠动力药KW-5092对豚鼠离体回肠蠕动的影响。
Effect of KW-5092, novel gastroprokinetic agent, on the peristalsis in the isolated guinea pig ileum.
作者信息
Suzuki M, Kishibayashi N, Yokoyama T, Karasawa A
机构信息
Department of Pharmacology, Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan.
出版信息
Jpn J Pharmacol. 1997 May;74(1):91-4. doi: 10.1254/jjp.74.91.
We examined the effect of KW-5092, a gastroprokinetic agent with acetylcholinesterase inhibitory and acetylcholine release facilitatory activities, on the peristalsis of isolated guinea pig ileum. KW-5092 (10(-9)-3 x 10(-6)M) increased the frequency of the peristaltic wave without changing its amplitude. Neostigmine increased the frequency at 10(-7) M, but domperidone (10(-8)-3 x 10(-6)M) had no effect on the peristalsis. The present results suggest that KW-5092 enhances the peristalsis via the inhibition of acetylcholinesterase, resulting in the intestinal propulsion.
我们研究了KW-5092（一种具有乙酰胆碱酯酶抑制和乙酰胆碱释放促进活性的胃肠动力药）对离体豚鼠回肠蠕动的影响。KW-5092（10^(-9)-3×10^(-6)M）增加了蠕动波的频率，而不改变其幅度。新斯的明在10^(-7)M时增加频率，但多潘立酮（10^(-8)-3×10^(-6)M）对蠕动没有影响。目前的结果表明，KW-5092通过抑制乙酰胆碱酯酶增强蠕动，从而促进肠道推进。
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