Yatsuhashi H, Yamasaki K, Aritomi T, Maria P, Carmen D, Inoue O, Koga M, Yano M
Institute for Clinical Research, Nagasaki Chuo National Hospital, Japan.
J Gastroenterol Hepatol. 1997 Jun;12(6):460-7. doi: 10.1111/j.1440-1746.1997.tb00467.x.
We analysed the expression of interferon (IFN) alpha/beta receptor mRNA in the liver of patients with chronic hepatitis C and examined the relationship between the expression of this receptor gene and the level of hepatitis C virus (HCV)-RNA as well as the response to 16 weeks of 6 x 10(6) units IFN. The mean level of IFN alpha/beta receptor mRNA in patients with chronic HCV infection (expressed as delta cycle; 10.8 +/- 1.9 (mean +/- SD); n = 39) was significantly higher than that of control subjects (9.4 +/- 0.5; n = 6; P < 0.01). There was a significant negative correlation between the level of IFN alpha/beta receptor mRNA and serum HCV-RNA in 39 patients with chronic hepatitis C (R = -0.546; P < 0.01). The mean level of IFN alpha/beta receptor mRNA in six patients who showed a complete response to IFN therapy (12.3 +/- 1.6) was higher than that of 15 patients who failed to respond to therapy (10.1 +/- 1.5; P < 0.01). Our results are consistent with the suggestion that the anti-viral activity of IFN depends on the level of the IFN alpha/beta receptor on hepatocytes in patients with chronic hepatitis C.
我们分析了慢性丙型肝炎患者肝脏中干扰素（IFN）α/β受体mRNA的表达情况，并研究了该受体基因的表达与丙型肝炎病毒（HCV）-RNA水平以及对6×10⁶单位干扰素治疗16周反应之间的关系。慢性HCV感染患者中IFNα/β受体mRNA的平均水平（以δ循环表示；10.8±1.9（平均值±标准差）；n = 39）显著高于对照组（9.4±0.5；n = 6；P < 0.01）。在39例慢性丙型肝炎患者中，IFNα/β受体mRNA水平与血清HCV-RNA之间存在显著负相关（R = -0.546；P < 0.01）。6例对干扰素治疗有完全反应的患者中IFNα/β受体mRNA的平均水平（12.3±1.6）高于15例治疗无反应患者（10.1±1.5；P < 0.01）。我们的结果与以下观点一致，即干扰素的抗病毒活性取决于慢性丙型肝炎患者肝细胞上IFNα/β受体的水平。
