人因子依赖性白血病细胞系

Human factor-dependent leukemia cell lines.

作者信息

Tohyama K

机构信息

Department of Laboratory Medicine and Clinical Sciences, Graduate School of Medicine, Kyoto University, Japan.

出版信息

Int J Hematol. 1997 Jun;65(4):309-17. doi: 10.1016/s0925-5710(96)00563-4.

DOI:10.1016/s0925-5710(96)00563-4

PMID:9195772

Abstract

To date several factor-dependent leukemia cell lines have been established. These cell lines have greatly contributed to the analyses of cytokine-mediated cellular signaling mechanisms involved in cell proliferation, differentiation and survival. In addition, they are ideal and practical models for testing the hypothesis regarding leukemogenesis. Taken together, factor-dependent leukemia cell lines are expected to be useful for studies on cell biology and development of new cancer therapeutics.

摘要

迄今为止，已经建立了几种因子依赖性白血病细胞系。这些细胞系对分析细胞增殖、分化和存活过程中涉及的细胞因子介导的细胞信号传导机制做出了巨大贡献。此外，它们是检验白血病发生假说的理想且实用的模型。综上所述，因子依赖性白血病细胞系有望用于细胞生物学研究和新型癌症治疗方法的开发。