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The FHIT gene, a multiple tumor suppressor gene encompassing the carcinogen sensitive chromosome fragile site, FRA3B.

作者信息

Huebner K, Hadaczek P, Siprashvili Z, Druck T, Croce C M

机构信息

Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107-5541, USA.

出版信息

Biochim Biophys Acta. 1997 Jun 7;1332(3):M65-70. doi: 10.1016/s0304-419x(97)00009-7.

DOI:10.1016/s0304-419x(97)00009-7
PMID:9196019
Abstract
摘要

相似文献

1
The FHIT gene, a multiple tumor suppressor gene encompassing the carcinogen sensitive chromosome fragile site, FRA3B.
Biochim Biophys Acta. 1997 Jun 7;1332(3):M65-70. doi: 10.1016/s0304-419x(97)00009-7.
2
FHIT gene and the FRA3B region are not involved in the genetics of renal cell carcinomas.脆性组氨酸三联体（FHIT）基因和FRA3B区域不参与肾细胞癌的遗传学过程。
Genes Chromosomes Cancer. 1997 Sep;20(1):9-15.
3
An FHIT tumor suppressor gene?一种FHIT肿瘤抑制基因？
Genes Chromosomes Cancer. 1998 Apr;21(4):281-9. doi: 10.1002/(sici)1098-2264(199804)21:4<281::aid-gcc1>3.0.co;2-v.
4
The role of the FHIT/FRA3B locus in cancer.FHIT/FRA3B基因座在癌症中的作用。
Annu Rev Genet. 1998;32:7-31. doi: 10.1146/annurev.genet.32.1.7.
5
Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: evolutionarily conserved but highly recombinogenic.脆性位点直系同源基因FHIT/FRA3B和Fhit/Fra14A2：进化保守但重组率高。
Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14988-93. doi: 10.1073/pnas.2336256100. Epub 2003 Nov 20.
6
Positions of chromosome 3p14.2 fragile sites (FRA3B) within the FHIT gene.FHIT基因内3号染色体3p14.2脆性位点（FRA3B）的位置。
Cancer Res. 1997 Mar 15;57(6):1166-70.
7
Sequence of the FRA3B common fragile region: implications for the mechanism of FHIT deletion.FRA3B常见脆性区域的序列：对FHIT基因缺失机制的启示
Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14584-9. doi: 10.1073/pnas.94.26.14584.
8
Induction of the common fragile site FRA3B does not affect FHIT expression.常见脆性位点FRA3B的诱导不影响FHIT表达。
Oncogene. 2001 Mar 29;20(14):1798-801. doi: 10.1038/sj.onc.1204243.
9
The Fragile Histidine Triad gene and breast cancer.脆性组氨酸三联体基因与乳腺癌
Med Sci Monit. 2002 Jul;8(7):RA140-4.
10
Identification of unstable sequences within the common fragile site at 3p14.2: implications for the mechanism of deletions within fragile histidine triad gene/common fragile site at 3p14.2 in tumors.3p14.2处常见脆性位点内不稳定序列的鉴定：对肿瘤中3p14.2处脆性组氨酸三联体基因/常见脆性位点内缺失机制的启示
Cancer Res. 2002 Jun 15;62(12):3477-84.

引用本文的文献

1
New Era of Mapping and Understanding Common Fragile Sites: An Updated Review on Origin of Chromosome Fragility.绘制与理解常见脆性位点的新时代：关于染色体脆性起源的最新综述
Front Genet. 2022 May 20;13:906957. doi: 10.3389/fgene.2022.906957. eCollection 2022.
2
Mycobacterial Populations Partly Change the Proportions of the Cells Undergoing Asymmetric/Symmetric Divisions in Response to Glycerol Levels in Growth Medium.在生长培养基中甘油水平的影响下，分枝杆菌种群部分改变了进行不对称/对称分裂的细胞的比例。
Cells. 2021 May 11;10(5):1160. doi: 10.3390/cells10051160.
3
Fragile sites in cancer: more than meets the eye.
癌症中的脆性位点：超乎所见。
Nat Rev Cancer. 2017 Jul 25;17(8):489-501. doi: 10.1038/nrc.2017.52.
4
Immunohistochemical characterization of FHIT expression in normal human tissues.人正常组织中FHIT表达的免疫组织化学特征
Interv Med Appl Sci. 2016 Mar;8(1):7-13. doi: 10.1556/1646.8.2016.1.1.
5
Absence of FHIT expression is associated with apoptosis inhibition in colorectal cancer.FHIT表达缺失与结直肠癌中的细胞凋亡抑制相关。
Front Med China. 2007 May;1(2):147-56. doi: 10.1007/s11684-007-0028-0. Epub 2007 May 1.
6
Aberrant crypt focus and fragile histidine triad protein in sporadic colorectal carcinoma.散发性结直肠癌中的异常隐窝病灶和脆弱组氨酸三联体蛋白。
World J Gastrointest Oncol. 2012 Dec 15;4(12):250-8. doi: 10.4251/wjgo.v4.i12.250.
7
High-resolution whole-genome analysis of skull base chordomas implicates FHIT loss in chordoma pathogenesis.颅底脊索瘤的高分辨率全基因组分析提示 FHIT 缺失在脊索瘤发病机制中的作用。
Neoplasia. 2012 Sep;14(9):788-98. doi: 10.1593/neo.12526.
8
Multiple Patterns of FHIT Gene Homozygous Deletion in Egyptian Breast Cancer Patients.埃及乳腺癌患者中FHIT基因纯合缺失的多种模式
Int J Breast Cancer. 2011;2011:325947. doi: 10.4061/2011/325947. Epub 2011 Oct 19.
9
Association of the promoter methylation and protein expression of Fragile Histidine Triad (FHIT) gene with the progression of differentiated thyroid carcinoma.脆性组氨酸三联体（FHIT）基因启动子甲基化及蛋白表达与分化型甲状腺癌进展的相关性
Int J Clin Exp Pathol. 2010 May 25;3(5):482-91.
10
Inhibition of topoisomerase I prevents chromosome breakage at common fragile sites.抑制拓扑异构酶 I 可防止常见脆性位点的染色体断裂。
DNA Repair (Amst). 2010 Jun 4;9(6):678-89. doi: 10.1016/j.dnarep.2010.03.005. Epub 2010 Apr 21.