The FHIT gene, a multiple tumor suppressor gene encompassing the carcinogen sensitive chromosome fragile site, FRA3B.

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作者信息

Huebner K, Hadaczek P, Siprashvili Z, Druck T, Croce C M

机构信息

Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107-5541, USA.

出版信息

Biochim Biophys Acta. 1997 Jun 7;1332(3):M65-70. doi: 10.1016/s0304-419x(97)00009-7.

DOI:10.1016/s0304-419x(97)00009-7

PMID:9196019

Abstract

摘要

相似文献

The FHIT gene, a multiple tumor suppressor gene encompassing the carcinogen sensitive chromosome fragile site, FRA3B.

Biochim Biophys Acta. 1997 Jun 7;1332(3):M65-70. doi: 10.1016/s0304-419x(97)00009-7.

FHIT gene and the FRA3B region are not involved in the genetics of renal cell carcinomas.脆性组氨酸三联体（FHIT）基因和FRA3B区域不参与肾细胞癌的遗传学过程。

Genes Chromosomes Cancer. 1997 Sep;20(1):9-15.

An FHIT tumor suppressor gene?一种FHIT肿瘤抑制基因？

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The role of the FHIT/FRA3B locus in cancer.FHIT/FRA3B基因座在癌症中的作用。

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Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: evolutionarily conserved but highly recombinogenic.脆性位点直系同源基因FHIT/FRA3B和Fhit/Fra14A2：进化保守但重组率高。

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Positions of chromosome 3p14.2 fragile sites (FRA3B) within the FHIT gene.FHIT基因内3号染色体3p14.2脆性位点（FRA3B）的位置。

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Sequence of the FRA3B common fragile region: implications for the mechanism of FHIT deletion.FRA3B常见脆性区域的序列：对FHIT基因缺失机制的启示

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Induction of the common fragile site FRA3B does not affect FHIT expression.常见脆性位点FRA3B的诱导不影响FHIT表达。

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The Fragile Histidine Triad gene and breast cancer.脆性组氨酸三联体基因与乳腺癌

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Identification of unstable sequences within the common fragile site at 3p14.2: implications for the mechanism of deletions within fragile histidine triad gene/common fragile site at 3p14.2 in tumors.3p14.2处常见脆性位点内不稳定序列的鉴定：对肿瘤中3p14.2处脆性组氨酸三联体基因/常见脆性位点内缺失机制的启示

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Mycobacterial Populations Partly Change the Proportions of the Cells Undergoing Asymmetric/Symmetric Divisions in Response to Glycerol Levels in Growth Medium.在生长培养基中甘油水平的影响下，分枝杆菌种群部分改变了进行不对称/对称分裂的细胞的比例。

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Immunohistochemical characterization of FHIT expression in normal human tissues.人正常组织中FHIT表达的免疫组织化学特征

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Aberrant crypt focus and fragile histidine triad protein in sporadic colorectal carcinoma.散发性结直肠癌中的异常隐窝病灶和脆弱组氨酸三联体蛋白。

World J Gastrointest Oncol. 2012 Dec 15;4(12):250-8. doi: 10.4251/wjgo.v4.i12.250.

High-resolution whole-genome analysis of skull base chordomas implicates FHIT loss in chordoma pathogenesis.颅底脊索瘤的高分辨率全基因组分析提示 FHIT 缺失在脊索瘤发病机制中的作用。

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Association of the promoter methylation and protein expression of Fragile Histidine Triad (FHIT) gene with the progression of differentiated thyroid carcinoma.脆性组氨酸三联体（FHIT）基因启动子甲基化及蛋白表达与分化型甲状腺癌进展的相关性

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Inhibition of topoisomerase I prevents chromosome breakage at common fragile sites.抑制拓扑异构酶 I 可防止常见脆性位点的染色体断裂。

DNA Repair (Amst). 2010 Jun 4;9(6):678-89. doi: 10.1016/j.dnarep.2010.03.005. Epub 2010 Apr 21.

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