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[抗生素类别及其作用机制]

[Classes of antibiotics and their mechanisms of action].

作者信息

Thrum H

出版信息

Z Gesamte Inn Med. 1977 Jul 15;32(14):Suppl: 209-14.

PMID:919647
Abstract

The antibiotics used in the chemotherapy of microbial infections are considered with respect to their antimicrobial spectra and their mechanisms of action, respectively. The sites of action of the different groups of antibiotics interfering with the same cellular processes are discussed. According to their primary actions on sensible cells the antimicrobial antibiotics are divided into four groups: 1. Inhibitors of the biosynthesis of the bacterial cell wall 2. Inhibitors of the bacterial protein synthesis 3. Inhibitors of the nucleic acid metabolism 4. Membrane-active antibiotics.

摘要

针对微生物感染化疗中使用的抗生素,分别从其抗菌谱和作用机制方面进行了考量。讨论了干扰相同细胞过程的不同组抗生素的作用位点。根据其对敏感细胞的主要作用,抗菌抗生素分为四类:1. 细菌细胞壁生物合成抑制剂;2. 细菌蛋白质合成抑制剂;3. 核酸代谢抑制剂;4. 膜活性抗生素。

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