小细胞肺癌患者与非小细胞肺癌患者及健康对照者的代谢比较。
Metabolism in patients with small cell lung carcinoma compared with patients with non-small cell lung carcinoma and healthy controls.
作者信息
Staal-van den Brekel A J, Schols A M, Dentener M A, ten Velde G P, Buurman W A, Wouters E F
机构信息
Department of Pulmonology, University Hospital, Masstricht, The Netherlands.
出版信息
Thorax. 1997 Apr;52(4):338-41. doi: 10.1136/thx.52.4.338.
BACKGROUND
Weight loss is a frequently occurring problem in patients with lung cancer due to an increased resting energy expenditure (REE) and a decreased energy intake. The aim of the present study was to compare the metabolic and inflammatory characteristics of patients with small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC). The metabolic parameters of the lung cancer population were compared with those of a healthy control group.
METHODS
REE was measured in 66 patients with lung cancer, subdivided according to their histology, and in 33 healthy controls matched for sex, age, and fat free mass (FFM). Inflammatory mediators were measured in the plasma of the patients with lung cancer.
RESULTS
An increased REE adjusted for FFM was found in the patients with lung cancer. Those with small cell lung carcinoma (SCLC) had an increased REE adjusted for FFM (mean 1925 kcal/day) compared with those with non-small cell lung carcinoma (NSCLC) (mean 1789 kcal/day, 95% CI for difference 36 to 236). FFM accounted for 69% and 48% of the inter-individual variation in REE in controls and those with NSCLC, respectively, while FFM accounted for only 25% of the variation in REE in patients with SCLC in whom the fat mass (FM) also contributed significantly (28%) to the variation in REE. Increased concentrations of soluble TNF-receptor 75 (sTNF-R75) and cortisol were found in patients with SCLC compared with those with NSCLC. Lipopolyasccharide binding protein (LBP) and sTNF-R55 were related to plasma levels of cortisol.
CONCLUSION
An enhanced REE adjusted for FFM occurred in patients with SCLC compared with those with NSCLC.
背景
由于静息能量消耗（REE）增加和能量摄入减少，体重减轻是肺癌患者中经常出现的问题。本研究的目的是比较小细胞肺癌（SCLC）和非小细胞肺癌（NSCLC）患者的代谢和炎症特征。将肺癌患者群体的代谢参数与健康对照组进行比较。
方法
对66例肺癌患者（根据组织学分类）以及33例性别、年龄和去脂体重（FFM）匹配的健康对照者测量REE。检测肺癌患者血浆中的炎症介质。
结果
肺癌患者中校正FFM后的REE增加。小细胞肺癌（SCLC）患者校正FFM后的REE（平均1925千卡/天）高于非小细胞肺癌（NSCLC）患者（平均1789千卡/天，差异的95%CI为36至236）。在对照组和NSCLC患者中，FFM分别占REE个体间差异的69%和48%，而在SCLC患者中，FFM仅占REE差异的25%，其中脂肪量（FM）也对REE差异有显著贡献（28%）。与NSCLC患者相比，SCLC患者中可溶性肿瘤坏死因子受体75（sTNF-R75）和皮质醇浓度升高。脂多糖结合蛋白（LBP）和sTNF-R55与血浆皮质醇水平相关。
结论
与NSCLC患者相比，SCLC患者校正FFM后的REE增强。
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