Rushton A R, Sneyd J R
Department of Anaesthesia, Derriford Hospital, Plymouth.
Br J Hosp Med. 1997;57(3):105-6.
This article discusses recent developments in opioid pharmacology. Selective activity at different opioid receptors promises, but has not yet provided, a strong analgesic without opioid side-effects. The startling pharmacokinetic profile of the new esterase-metabolized intravenous opioid, remifentanil, is reflected in the rapid onset of effect and short, predictable recovery, independent of duration of infusion.
本文讨论了阿片类药物药理学的最新进展。作用于不同阿片受体的选择性活性虽有望实现，但尚未提供一种无阿片类药物副作用的强效镇痛药。新型酯酶代谢的静脉用阿片类药物瑞芬太尼惊人的药代动力学特征表现为起效迅速且恢复短暂、可预测，与输注持续时间无关。
